Not sure if I should post this in this section or the render section but....
Does anyone know if it is possible to modify the default Render Output settings so that every time I open Keyshot (10) it has a predetermined "Print Size" and the file name does not include the "System Render #"?
It should work, if you create a blank scene with the settings, HDRI and all the other stuff and save it in the wcenes folder (or other path). Then you can use this as a custom default scene set into the preferences.