I have the same problem, but in Windows 7. The really annoying thing is that it used to work. I've been working with Alias and KeyShot for years and up until recently I've been able to open .wire files in keyshot without a hitch. Now every time I try to do it I get this error message. I've been emailing someone in the support dept but so far he hasn't told me anything new or helpful, just that it should work and it works for him. I know it *should* work, it just doesn't and I can't figure out what happened.