I was int he same boat 1 year ago when I left my job and went freelance. I walked into the local computer part place and gave them my budget of $2500 and told them to build something around the GTX1080 which just came out. I was going to be doing a lot of GPU rendering at the time. The nerds came crawling up and over the shelves and from underneath the displays to watch someone build a system with the budget that large, the guy said normally people start to complain about spending more the $600 on a PC build!
But, like you I knew next to nothing. It appears that nowadays, compared to 10 years ago, its pretty much all plug n play. Especially with sites like PC Parts picker that check for card clearances, compatibility, PSU requirements, etc. No guessing, just pick your specs and go with it. Being a mac guy for the past 15 years, I had never built a windows PC, i had repaired and beefed up countless Macs though. My 13 year old son and I built the PC and got windows up and running within 2 hours. It was crazy, like a big boy lego kit. Every thing just fit together. Was really fun. The process of loading drivers and other software took another couple hours, but I really didn't have any problems.
I would say, I would do different is build as much of the mother board (CPU, cooler, ram, etc) outside the case. I mounted my board first then proceeded to have to remove it twice because of routing cables, and whoops forgot to put the thermal paste on the CPU. Lesson learned.
I don't know much about the particular parts you picked, but I would really take a minute to research the warranties of the major parts. I had my motherboard die about 1 month ago, and it had a good warranty, Gigabyte repaired it and I had it back within 2 weeks. But, I was close to just buying another one since I had work waiting.
The other thing is that with those CPU's, I think you might have 4 channels of RAM slots available, and you would want to populate those 4 channels with one stick each, so you might be better off getting 4 sticks of 16 GB rather than the 2 of 32. I could be wrong on that , but from what I read that's the preferred way of doing it. I have 4 sticks of 8GB and works pretty well. I don't overclock or anything either, so I have air coolers as well.
have fun and keep us posted!